Key result
Skeletal muscle blood flow can increase by more than 20-fold during intense exercise, and exercise training induces an adaptive vascular transformation that promotes overall cardiovascular health.
Design
Review
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Exercise training supports vascular health; leaves open optimal dosing and mechanisms for clinical translation.
This review summarizes the mechanisms of skeletal muscle blood flow regulation at rest and during exercise, highlighting its role in cardiovascular health and disease.
Ronald J. Korthuis (2011) conducted a review in Skeletal muscle circulation physiology and pathology. Skeletal muscle blood flow can increase by more than 20-fold during intense exercise, and exercise training induces an adaptive vascular transformation that promotes overall cardiovascular health.
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