Key result
Cross-linking of actin filaments by filamin increased filament elasticity and stiffness, with actin networks forming at a filamin/actin molar ratio of less than 1:100.
Population
Actin-gelsolin networks
Comparison
Filamin cross-linking vs Different molar ratios of filamin/actin and…
Design
Preclinical
Authors
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Increases actin stiffness via filamin cross-linking; leaves open cytoskeletal roles in cardiac mechanics.
Filamin cross-linking increases the elasticity and stiffness of actin filaments, with the required ratio depending on filament length distribution.
Goldmann et al. (1997) studied this question. Filamin cross-linking was evaluated on Viscoelasticity and stiffness of actin-gelsolin networks. Cross-linking of actin filaments by filamin increased filament elasticity and stiffness, with actin networks forming at a filamin/actin molar ratio of less than 1:100.
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