Key result
Long-term physical training was associated with higher basal plasma nitrites (4.9 vs 1.9; P<0.05) and nitrates, but acute exercise did not produce differences in the increments of these metabolites.
Why the study?
Does acute physical exercise and long-term physical training alter the production of nitric oxide metabolites, ANP, and cGMP in healthy volunteers?
Population
20 healthy volunteers (10 trained athletes and 10 untrained people)
Comparison
Maximal treadmill test (acute physical exercise) vs Untrained people and pre-exercise baseline
Design
Cross-sectional
Authors
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May link NO/ANP/cGMP pathways to exercise vasodilation; leaves open causal confirmation in larger trials.
Observational (n=20)
Does acute physical exercise and long-term physical training alter the production of nitric oxide metabolites, ANP, and cGMP in healthy volunteers?
Absolute Event Rate: 4.9% vs 1.9%
p-value: p=<0.05
Long-term physical training increases basal levels of plasma nitrite and nitrate, but acute exercise does not augment the release of nitric oxide differently in trained versus untrained subjects.
Poveda et al. (1997) conducted an observational in Healthy volunteers (n=20). Long-term physical training vs. Untrained status was evaluated on Basal plasma nitrites (p=<0.05). Long-term physical training was associated with higher basal plasma nitrites (4.9 vs 1.9; P<0.05) and nitrates, but acute exercise did not produce differences in the increments of these metabolites.
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