March 1, 1997Journal of Applied Physiology

Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Healthy. Intervention: Physical fitness (athletic status) and acute exercise vs. Nonathletic controls and resting state. Primary outcome: Resting plasma nitrate (microM) (p=< 0.01).

Q: What question did this study set out to answer?

To investigate the relationship between physical fitness, acute exercise, and nitric oxide production in healthy humans.

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Key result

Athletic subjects had higher resting plasma nitrate than nonathletic controls (45 vs 34 microM; P<0.01), and 2 hours of exercise acutely elevated plasma nitrate in both groups.

Why the study?

Does physical fitness and acute exercise increase nitric oxide formation in healthy humans?

Population

Healthy subjects with different working capacities (athletic subjects and nonathletic controls)

Comparison

2 hours of physical exercise vs Resting state before exercise; nonathletic…

Design

Cross-sectional

Follow-up

2 hours

Authors

LJLennart JungerstenSahlgrenska University Hospital AAAnneli AmbringCentre of Registers Vastra Gotaland BWBjörn WallSahlgrenska University Hospital

Discussion

Member takes

Implication

Higher nitrate may mark fitness; leaves open causal NO role in exercise capacity.

Key Points

To investigate the relationship between physical fitness, acute exercise, and nitric oxide production in healthy humans.
Analyzed plasma and urine nitrate levels in healthy subjects with varying fitness levels.
Measured resting plasma nitrate and urinary excretion of nitrate alongside peak work rates via bicycle ergometry.
Compared changes in plasma nitrate before and after 2 hours of exercise in athletes and nonathletes.
Resting plasma nitrate was significantly higher in athletic subjects (45 +/- 2 microM) compared to nonathletic controls (34 +/- 2 microM; P < 0.01).
Resting plasma nitrate and urinary nitrate excretion showed significant positive correlations with peak work rates (r = 0.53 and r = 0.46; P < 0.01).
A single exercise session increased plasma nitrate by 18 +/- 4% in athletes and 16 +/- 6% in non-athletes (P < 0.01).

Study Design

Type

Observational

Structured PICO

Does physical fitness and acute exercise increase nitric oxide formation in healthy humans?

Population

Healthy subjects with different working capacities assessed for the relationship between physical fitness, acute exercise, and nitric oxide formation.

Exposure

2 hours of physical exercise

Comparator

Resting state before exercise; nonathletic controls

Outcome

Nitrate levels in plasma and urine (stable end product of nitric oxide metabolism)surrogate

Main Result

Absolute Event Rate: 45% vs 34%

p-value: p=< 0.01

Cite This Study

Jungersten et al. (1997) conducted an observational in Healthy. Physical fitness (athletic status) and acute exercise vs. Nonathletic controls and resting state was evaluated on Resting plasma nitrate (microM) (p=< 0.01). Athletic subjects had higher resting plasma nitrate than nonathletic controls (45 vs 34 microM; P<0.01), and 2 hours of exercise acutely elevated plasma nitrate in both groups.

synapsesocial.com/papers/6a63d4ceccedfd04c99278df https://doi.org/10.1152/jappl.1997.82.3.760

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Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider