Key result
A combined abnormality in heart rate variability and QTc interval strongly predicted mortality in type 1 diabetes compared to normal values (adjusted HR 6.7; 95% CI 1.8-25; p=0.005).
Why the study?
Does a combined abnormality in heart rate variability and QTc interval predict mortality in patients with type 1 diabetes?
Population
391 type 1 diabetic mellitus patients, mean age 41.8 years, mean duration of DM 27.3 years, followed in an…
Comparison
Presence of combined abnormality in heart rate… vs Normal heart rate variability and normal QTc…
Design
Cohort
Follow-up
10 years
Authors
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May identify high-risk type 1 diabetes patients for monitoring; hypothesis-generating for interventions pending prospective trials.
Cohort (n=391)
Does a combined abnormality in heart rate variability and QTc interval predict mortality in patients with type 1 diabetes?
Hazard Ratio: 6.7 (95% CI 1.8–25)
p-value: p=0.005
A combined abnormality in heart rate variability and QTc interval is a strong, independent predictor of mortality in patients with type 1 diabetes.
Lykke et al. (2008) conducted a cohort in type 1 diabetes (n=391). Combined abnormality in heart rate variability and QTc interval vs. Normal test values for both parameters was evaluated on Mortality (HR 6.7, 95% CI 1.8-25, p=0.005). A combined abnormality in heart rate variability and QTc interval strongly predicted mortality in type 1 diabetes compared to normal values (adjusted HR 6.7; 95% CI 1.8-25; p=0.005).
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