Endothelin concentrations in recipient twins with twin-twin transfusion syndrome were 2.5 times higher than in their donor co-twins both in utero (P<0.001) and at birth (P<0.01).
Observational (n=20)
Are endothelin (ET-1) concentrations elevated in monochorionic twins with severe twin-twin transfusion syndrome compared to those without?
Endothelin-1 concentrations are significantly elevated in recipient twins of twin-twin transfusion syndrome, correlating with the severity of hydrops, suggesting a role in the pathophysiology of the condition.
Effect estimate: 2.5 times higher
p-value: p=<0.001
The objective of this study was to determine endothelin (ET-1) concentrations in monochorionic twin fetuses with and without twin-twin transfusion syndrome (TTTS). Fourteen monochorionic twin pregnancies complicated by TTTS and six without TTTS were studied. Matched maternal and fetal blood samples were obtained both in utero and at birth. Amniotic fluid samples were also collected from twin pairs. ET-1 concentrations were measured by radio-immunoassay. ET-1 concentrations in recipient fetuses were higher than in the donors both in utero(P < 0.001) and at birth (P < 0.01). Fetal concentrations of ET-1 in donors were similar to non-TTTS twins. Plasma ET-1 concentrations were significantly higher (P < 0.01) in recipient fetuses with severe hydrops than those with mild/no hydrops. Maternal concentrations of ET-1 were comparable in the two groups. Endothelin concentrations in recipient twins were 2(1/2) times higher than in their co-twins and this was related to the severity of hydrops.
Bajoria et al. (Tue,) conducted a observational in Twin-twin transfusion syndrome (n=20). Recipient status in twin-twin transfusion syndrome vs. Donor co-twins and non-TTTS twins was evaluated on Endothelin (ET-1) concentrations (2.5 times higher, p=<0.001). Endothelin concentrations in recipient twins with twin-twin transfusion syndrome were 2.5 times higher than in their donor co-twins both in utero (P<0.001) and at birth (P<0.01).