Key result
Fetal breathing initiation was associated with an increase in umbilical artery endothelin-1 concentration from 14.9 to 93.7 pmol/l, suggesting a role in umbilical vessel closure at delivery.
Population
Pregnant women and their fetuses/neonates
Design
Cross-sectional
Authors
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Endothelin-1 rise with fetal breathing may aid vessel closure; leaves open causal role and neonatal relevance.
Observational
Endothelin-1 levels are significantly elevated in umbilical blood after the initiation of fetal breathing, suggesting a role in fetal hemodynamic changes such as umbilical vessel closure at delivery.
Nisell et al. (2010) conducted an observational in Pregnancy. Fetal breathing and delivery vs. Before breathing and early mid-trimester was evaluated on Endothelin-like immunoreactivity (ET-LI) concentration. Fetal breathing initiation was associated with an increase in umbilical artery endothelin-1 concentration from 14.9 to 93.7 pmol/l, suggesting a role in umbilical vessel closure at delivery.
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