Key result
Fetal endothelin 1-21 levels exceed maternal levels by ~77% and show no correlation.
Population
20 'mother-fetus' pairs, involving non-malformed appropriate for gestational age fetuses of 18-24 weeks…
Design
Cross-sectional
Authors
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Fetal-maternal endothelin dissociation supports independent production; leaves open its role in fetal vascular regulation and need for targeted perinatal studies.
Cross-Sectional (n=20)
Absolute Event Rate: 11.39% vs 6.44%
p-value: p=< 0.01
Fetal endothelin levels are significantly higher than maternal levels and lack correlation, suggesting independent fetal production that may contribute to normal growth and vascular regulation.
Malamitsi-Puchner et al. (1995) conducted a cross-sectional in Normal pregnancy (n=20). Fetal endothelin (ET 1-21) levels vs. Maternal endothelin (ET 1-21) levels was evaluated on Endothelin 1-21 plasma levels (p=< 0.01). Fetal endothelin 1-21 levels (11.39 pmol/L) were significantly higher than maternal levels (6.44 pmol/L; p < 0.01), with no correlation found between them.
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