Key result
Pre-eclampsia was associated with increased maternal plasma ET-1 levels and intense immunoreactive ET-1 labelling in fetal membranes compared to normal pregnancy.
Observational
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Increased endothelin-1 levels and intense immunolocalisation in fetal membranes of pre-eclamptic women suggest a paracrine/autocrine role in the hypertension and vasospasm of the syndrome.
Maternal plasma ET-1 levels and the immunolocalisation of ET1 in the fetal membranes of pre-eclamptic primigravidae at >/=28 weeks, gestation were studied. The levels of maternal plasma ET1 and immunoreactive ET-1 were increased in pre-eclampsia. Immunoreactive ET-1 was localised in the amnion, chorion and decidua of normal pregnant women as well as those with preeclampsia-eclampsia. Intense labelling was observed in moderate pre-eclampsia (BP 140/90 - 170/110 mmHg) with very intense labelling in severe pre-eclampsia (BP >170/110 mmHg), especially in the amniotic epithelium, chorionic villi, maternal blood vessels, cytotrophoblasts and giant cells of the decidua. The increased ET-1 levels demonstrated in fetal membranes of pre-eclamptic women are probably produced in a paracrine and/or autocrine manner, contributing to the hypertension, vasospasm and fetal growth restriction characteristic of the syndrome. A larger study would be required to show significant change in endothelin production in pre-eclampsia.
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A 2001 study conducted an observational in Pre-eclampsia. Pre-eclampsia vs. Normal pregnancy was evaluated on Maternal plasma ET-1 levels and immunolocalisation of ET-1 in fetal membranes. Pre-eclampsia was associated with increased maternal plasma ET-1 levels and intense immunoreactive ET-1 labelling in fetal membranes compared to normal pregnancy.
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