Key result
Titin PEVK segments contain abundant overlapping SH3 ligand motifs that bind to nebulin SH3 in opposite orientations, suggesting a role as major hubs for SH3-dependent signaling pathways.
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No immediate clinical implications for titin-related cardiomyopathies; leaves open functional roles in cardiac mechanosignaling for targeted research.
Ma et al. (2006) studied this question. Titin SH3 ligand motifs was evaluated on Binding affinity and orientation of titin-based SH3 ligands toward nebulin SH3. Titin PEVK segments contain abundant overlapping SH3 ligand motifs that bind to nebulin SH3 in opposite orientations, suggesting a role as major hubs for SH3-dependent signaling pathways.
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