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January 1, 2007Nordic Journal of Psychiatry

Mortality in relation to self-reported mixed anxiety and depression symptoms – The HUNT study

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Key result

Self-reported mixed anxiety and depression symptoms (HADS-T ≥25 points) were associated with increased mortality risk over 4.5 years (P=0.043), with a significant dose-response trend (P=0.02).

Why the study?

Do self-reported mixed anxiety and depression symptoms increase mortality risk in the general population?

Population

2624 individuals from a general population survey

Comparison

High self-reported mixed anxiety and depression… vs Low symptom score (HADS-T score 0-19 points)

Design

Cohort

Follow-up

4.5 years

Authors

OBOttar BjerkesetNorwegian University of Science and TechnologyAMArnstein MykletunNorwegian Institute of Public HealthADAlv A. DahlOslo University Hospital

Discussion

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Member takes

Implication

May warrant screening for mixed anxiety-depression; leaves open whether intervention reduces mortality risk.

Study Design

Type

Cohort (n=2,624)

Structured PICO

Do self-reported mixed anxiety and depression symptoms increase mortality risk in the general population?

P
Population
2,624 individuals from the general population followed for 4.5 years to assess mortality in relation to self-reported mixed anxiety and depression symptoms.
E
Exposure
High self-reported mixed anxiety and depression symptoms (HADS-T score 19-24 points or ≥25 points)
C
Comparator
Low symptom score (HADS-T score 0-19 points)
O
Outcome
Total mortality over 4.5 yearshard clinical

Main Result

p-value: p=0.043

Self-reported mixed anxiety and depression symptoms show a dose-response relationship with increased total mortality risk over 4.5 years.

Limitations

  • Limited sample size making findings tentative

Cite This Study

Bjerkeset et al. (2007) conducted a cohort in Mixed anxiety and depression (n=2,624). Self-reported mixed anxiety and depression symptoms (HADS-T score ≥25 points) vs. Lower HADS-T score groups (0-19 points) was evaluated on Total mortality (p=0.043). Self-reported mixed anxiety and depression symptoms (HADS-T ≥25 points) were associated with increased mortality risk over 4.5 years (P=0.043), with a significant dose-response trend (P=0.02).

synapsesocial.com/papers/6a63daa02cb75007f492744bhttps://doi.org/10.1080/08039480601121926
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Suicide and Mortality Patterns in Anxiety Neurosis and Depressive Neurosis1994 · 82 citations
  2. 2Severity of depressive episodes according to ICD-10: prediction of risk of relapse and suicide2004 · 101 citations
  3. 3COMORBIDITY OF ANXIETY AND UNIPOLAR MOOD DISORDERS1998 · 1,588 citations
  4. 4Association between major depressive disorder and physical illness1993 · 135 citations
  5. 5Can We Distinguish Anxiety From Depression?2015 · 60 citations