Key result
Severe symptoms of depression were associated with an increased risk of incident heart failure (HR 1.41; 95% CI 1.07-1.87; P for trend=0.026), whereas anxiety or mixed symptoms showed no excess risk.
Why the study?
Do symptoms of anxiety and depression increase the risk of incident heart failure in adults without known heart failure?
Population
62,567 adults free of known heart failure at baseline, from the Nord-Trøndelag Health Study in Norway.
Comparison
Self-reported symptoms of depression, anxiety… vs Absence of or lower severity of…
Design
Cohort
Follow-up
mean 11.3 years
Authors
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Depression symptoms may warrant attention in HF risk assessment; leaves open whether treatment reduces incident HF.
Cohort (n=62,567)
Do symptoms of anxiety and depression increase the risk of incident heart failure in adults without known heart failure?
Effect estimate: HR 1.41 (95% CI 1.07-1.87)
p-value: p=0.026
Severe symptoms of depression, but not anxiety, are independently associated with a significantly increased risk of developing incident heart failure.
Gustad et al. (2014) conducted a cohort in Heart failure (n=62,567). Symptoms of depression vs. No or mild symptoms was evaluated on Incident heart failure (HR 1.41, 95% CI 1.07-1.87, p=0.026). Severe symptoms of depression were associated with an increased risk of incident heart failure (HR 1.41; 95% CI 1.07-1.87; P for trend=0.026), whereas anxiety or mixed symptoms showed no excess risk.
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