June 19, 2007Echocardiography
Prognostic Role of Left Atrial Volume in Elderly Patients with Symptomatic Stable Chronic Heart Failure: Comparison with Left Ventricular Diastolic Dysfunction and B‐Type Natriuretic Peptide
Key result
Left atrial volume index was the only independent predictor of all-cause mortality and heart failure hospitalization in stable chronic HF (HR 1.03 per 1 ml/m2 increase; 95% CI 1.01-1.06; P=0.02).
Why the study?
Does left atrial volume index predict mortality and heart failure hospitalization better than LVDD and BNP in elderly patients with symptomatic stable chronic heart failure?
Population
46 patients with symptomatic stable chronic heart failure, in sinus rhythm, without significant valvular…
Comparison
Measurement of left atrial volume indexed to… vs Left ventricular diastolic dysfunction and…
Design
Cohort
Follow-up
20 +/- 14 months
Authors
Discussion
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Member takes
Implication
LAVi independently predicted outcome in small HF cohort; hypothesis-generating and requires validation before clinical use.
Study Design
Type
Cohort (n=46)
Structured PICO
Does left atrial volume index predict mortality and heart failure hospitalization better than LVDD and BNP in elderly patients with symptomatic stable chronic heart failure?
P
Population
46 elderly patients with symptomatic stable chronic heart failure in sinus rhythm, followed for a mean of 20 months.
E
Exposure
Measurement of left atrial volume indexed to body surface area (LAVi)
C
Comparator
Left ventricular diastolic dysfunction (LVDD) and B-type natriuretic peptide (BNP) levels
O
Outcome
Composite of all-cause mortality and hospitalization for worsening HFcomposite
Main Result
Hazard Ratio: 1.03 (95% CI 1.01–1.06)
p-value: p=0.02
Left atrial volume index is an independent predictor of mortality and heart failure hospitalization in elderly patients with stable chronic heart failure, outperforming BNP and left ventricular diastolic dysfunction.
Cite This Study
Popescu et al. (2007) conducted a cohort in Symptomatic stable chronic heart failure (n=46). Left atrial volume index (LAVi) was evaluated on Combined all-cause mortality and hospitalization for worsening HF (HR 1.03, 95% CI 1.01-1.06, p=0.02). Left atrial volume index was the only independent predictor of all-cause mortality and heart failure hospitalization in stable chronic HF (HR 1.03 per 1 ml/m2 increase; 95% CI 1.01-1.06; P=0.02).