Non-alcoholic fatty liver disease was independently associated with a 10-year increased risk of incident atrial fibrillation in type 2 diabetic patients (HR 4.96; 95% CI 1.42-17.28).
Meta-Analysis
Does non-alcoholic fatty liver disease increase the risk of atrial fibrillation in adult individuals?
NAFLD is independently associated with an increased risk of atrial fibrillation, particularly in patients with type 2 diabetes, suggesting a potential need for heightened AF surveillance in this population.
Hazard Ratio: 4.96 (95% CI 1.42–17.28)
BACKGROUND random-effects odds ratio 5.17, 95% CI 2.05-13.02). Meta-analysis of data from 4 longitudinal studies showed that NAFLD was independently associated with a 10-year increased risk of incident AF only in type 2 diabetic patients (n = 1 study; random-effects hazard ratio 4.96, 95% CI 1.42-17.28). Sensitivity analyses did not modify these findings. Funnel plots did not reveal significant publication bias. CONCLUSIONS: NAFLD is associated with an increased risk of AF in middle-aged and elderly individuals (especially in those with type 2 diabetes). However, the observational design of the eligible studies does not allow for proving causality.
Mantovani et al. (Fri,) conducted a meta-analysis in Non-alcoholic fatty liver disease and atrial fibrillation. Non-alcoholic fatty liver disease (NAFLD) vs. No NAFLD was evaluated on Incident atrial fibrillation in type 2 diabetic patients (HR 4.96, 95% CI 1.42-17.28). Non-alcoholic fatty liver disease was independently associated with a 10-year increased risk of incident atrial fibrillation in type 2 diabetic patients (HR 4.96; 95% CI 1.42-17.28).