Non-Alcoholic Fatty Liver Disease Is Associated with an Increased Incidence of Atrial Fibrillation in Patients with Type 2 Diabetes
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Why the study?
Does non-alcoholic fatty liver disease (NAFLD) increase the incidence of atrial fibrillation in patients with type 2 diabetes?
Population
400 patients with type 2 diabetes, clinically free from atrial fibrillation at baseline, randomly selected…
Comparison
Presence of non-alcoholic fatty liver disease… vs Absence of non-alcoholic fatty liver disease at…
Design
Cohort, Hepatic ultrasonography was performed by a radiologist blinded to…
Follow-up
10 years
Authors
Discussion
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Implication
May warrant AF surveillance in T2DM with NAFLD; hypothesis-generating and requires prospective validation.
Structured PICO
Does non-alcoholic fatty liver disease (NAFLD) increase the incidence of atrial fibrillation in patients with type 2 diabetes?
P
Population
400 patients with type 2 diabetes, clinically free from atrial fibrillation at baseline, randomly selected from a cohort of 1,718 outpatients at a single center in Italy. Mean age 64, 58.7% male. Key exclusions: history of AF/atrial flutter, anti-arrhythmic drugs, moderate-to-severe valvular disease, hyperthyroidism, end-stage renal disease, or known causes of chronic liver disease.
I
Intervention
Presence of non-alcoholic fatty liver disease (NAFLD) diagnosed by ultrasonographic detection of hepatic steatosis at baseline.
C
Comparator
Absence of non-alcoholic fatty liver disease (NAFLD) at baseline.
O
Outcome
Incident atrial fibrillation (AF) confirmed by a standard 12-lead electrocardiogram over 10 years of follow-up.hard clinical
Ultrasound-diagnosed non-alcoholic fatty liver disease is strongly and independently associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes.
Limitations
- Small number of incident AF events (n=42)
- 24-hour Holter monitor examination was not routinely performed, potentially missing asymptomatic AF
- Semi-quantitative sonographic scoring for the degree of hepatic steatosis was not available
- Reduced sensitivity of ultrasonography when hepatic fat infiltration is <33%
Cite This Study
Targher et al. (2013) studied this question.
Topics
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