Key result
Systemic treatment with superoxide scavengers Tempol or Tiron prevented the loss of microvessels in spontaneously hypertensive rats (411 and 399 mm/mm3 vs 371 mm/mm3 in untreated controls).
Why the study?
Does antioxidant treatment with superoxide scavengers prevent endothelial cell apoptosis and microvessel rarefaction in spontaneously hypertensive rats?
Population
Juvenile spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats
Comparison
Systemic treatment with superoxide scavengers… vs Untreated age-matched controls (SHR and WKY rats)
Design
Preclinical
Follow-up
Evaluated at 16 weeks of age
Authors
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Antioxidants may limit endothelial apoptosis and rarefaction in hypertensive rats; leaves open translation to human hypertension therapy.
Does antioxidant treatment with superoxide scavengers prevent endothelial cell apoptosis and microvessel rarefaction in spontaneously hypertensive rats?
Absolute Event Rate: 411% vs 371%
p-value: p=<0.01
Antioxidant treatment with superoxide scavengers inhibits endothelial cell apoptosis and prevents microvessel rarefaction in spontaneously hypertensive rats.
Kobayashi et al. (2005) studied Hypertension. Superoxide scavengers (Tempol or Tiron) vs. Untreated age-matched controls was evaluated on Microvessel length density (p=<0.01). Systemic treatment with superoxide scavengers Tempol or Tiron prevented the loss of microvessels in spontaneously hypertensive rats (411 and 399 mm/mm3 vs 371 mm/mm3 in untreated controls).
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