Key result
Severe tricuspid regurgitation was significantly associated with higher all-cause mortality at 3 years compared with no tricuspid regurgitation (AdjHR 2.40; 95% CI 2.16-2.66).
Why the study?
Tricuspid regurgitation is associated with increased morbidity and mortality, but further assessment of clinical profiles and long-term outcomes across varying degrees of TR was needed using institutional registry data.
Does moderate or severe tricuspid regurgitation increase the risk of all-cause mortality and hospitalization compared to no tricuspid regurgitation in patients undergoing echocardiography?
Population
88,511 unique individuals in an institutional echocardiographic registry
Comparison
Varying degrees of TR (mild, moderate, or severe vs no reported TR)
Design
Institutional registry-based cross-sectional analysis
Follow-up
3 years
Authors
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Supports TR severity for risk stratification on routine echo; leaves open whether intervention alters long-term outcomes.
Cross-Sectional (n=88,511)
No
Does moderate or severe tricuspid regurgitation increase the risk of all-cause mortality and hospitalization compared to no tricuspid regurgitation in patients undergoing echocardiography?
Hazard Ratio: 2.4 (95% CI 2.16–2.66)
Moderate and severe tricuspid regurgitation are independently associated with a significantly increased risk of 3-year all-cause mortality and hospitalization, highlighting the need for close clinical monitoring and potential intervention.
Sammour et al. (2025) conducted a cross-sectional in Tricuspid regurgitation (n=88,511). Severe tricuspid regurgitation vs. No tricuspid regurgitation was evaluated on All-cause mortality at 3 years from the index echocardiogram (AdjHR 2.40, 95% CI 2.16-2.66). Severe tricuspid regurgitation was significantly associated with higher all-cause mortality at 3 years compared with no tricuspid regurgitation (AdjHR 2.40; 95% CI 2.16-2.66).
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