Key result
Human-induced pluripotent stem cell-derived cardiomyocytes of cardiac origin showed improved differentiation efficiency but no major functional differences compared to those of fibroblastic origin.
Population
Human-induced pluripotent stem cell-derived cardiomyocytes generated from adult cardiac-stromal progenitor…
Comparison
Selective ionic current blockade vs hiPSC-derived cardiomyocytes of fibroblastic…
Design
Preclinical
Authors
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CPC-derived hiPSC-CMs may refine arrhythmia models in vitro; leaves open clinical translation and source-specific effects.
hiPSC-derived cardiomyocytes generated from cardiac-stromal progenitor cells show improved cardiac differentiation efficiency but similar electrophysiological responses to ionic current blockade compared to those from skin fibroblasts.
Altomare et al. (2016) studied this question. hiPSC-derived cardiomyocytes of cardiac origin vs. hiPSC-derived cardiomyocytes of fibroblastic origin was evaluated on Sensitivity to selective ionic current blockade and cardiac differentiation efficiency. Human-induced pluripotent stem cell-derived cardiomyocytes of cardiac origin showed improved differentiation efficiency but no major functional differences compared to those of fibroblastic origin.
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