Key result
In silico hiPSC-CMs and hAdultV-CMs showed similar qualitative responses to selective ionic current block, but hiPSC-CMs were quantitatively more sensitive to L-type Ca2+ and inward rectifier K+ block.
Population
In silico action potential models of ventricular-like and atrial-like human-induced pluripotent stem…
Comparison
Simulated selective ionic current block vs Comparison between hiPSC-CM and hAdultV-CM models
Design
Preclinical
Authors
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hiPSC-CMs show greater sensitivity to ionic block than hAdultV-CMs; leaves open combined use to replace hERG QT studies pending validation.
In silico models demonstrate that hiPSC-CMs exhibit greater sensitivity to ionic current block than adult ventricular cardiomyocytes, supporting their use in in vitro pharmacological safety assessments.
Paci et al. (2015) studied this question. Selective ionic current block vs. Human adult ventricular cardiomyocyte (hAdultV-CM) models was evaluated on Effects on action potentials (APs). In silico hiPSC-CMs and hAdultV-CMs showed similar qualitative responses to selective ionic current block, but hiPSC-CMs were quantitatively more sensitive to L-type Ca2+ and inward rectifier K+ block.
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