Key result
Pravastatin significantly improved adenosine-induced myocardial blood flow in young men with mild hypercholesterolemia only when baseline ADMA concentrations were low (+35% change, p=0.004).
Why the study?
Does pravastatin improve myocardial blood flow in young adult men with mild hypercholesterolemia, and is this effect modified by baseline ADMA levels?
RCT (n=51)
Does pravastatin improve myocardial blood flow in young adult men with mild hypercholesterolemia, and is this effect modified by baseline ADMA levels?
Effect estimate: Change +35%
p-value: p=0.004
Baseline ADMA levels modify the microvascular benefits of pravastatin, with improvements in myocardial blood flow limited to patients with low ADMA.
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ADMA modifies pravastatin's effect on myocardial blood flow; extends evidence that baseline ADMA identifies statin responders in mild hypercholesterolemia.
Janatuinen et al. (2003) conducted an RCT in mild hypercholesterolemia (n=51). Pravastatin vs. placebo was evaluated on adenosine-induced myocardial blood flow (Change +35%, p=0.004). Pravastatin significantly improved adenosine-induced myocardial blood flow in young men with mild hypercholesterolemia only when baseline ADMA concentrations were low (+35% change, p=0.004).
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