February 1, 2003Journal of Cardiovascular Pharmacology
Effect of High-Dose Statin Treatment on Plasma Concentrations of Endogenous Nitric Oxide Synthase Inhibitors
Key result
High-dose statin treatment with simvastatin or atorvastatin effectively lowered LDL cholesterol but did not change plasma concentrations of ADMA or LMMA.
Why the study?
Does high-dose statin treatment reduce plasma levels of ADMA and LMMA in subjects with mild hypercholesterolemia?
Population
n=48 subjects with mild hypercholesterolemia
Comparison
Simvastatin 80 mg/d or atorvastatin 40 mg/d for… vs Placebo
Design
RCT, randomly assigned, double-blind
Follow-up
8 weeks
Authors
Discussion
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Implication
High-dose statins lower LDL without altering ADMA or LMMA; challenges hypotheses that these markers mediate statin effects on nitric oxide synthase.
Study Design
Type
RCT (n=48)
Blinding
Double-blind
Randomization
Randomly assigned
Structured PICO
Does high-dose statin treatment reduce plasma levels of ADMA and LMMA in subjects with mild hypercholesterolemia?
P
Population
48 subjects with mild hypercholesterolemia treated for 8 weeks.
I
Intervention
Simvastatin 80 mg/d or atorvastatin 40 mg/d for 8 weeks
C
Comparator
Placebo
O
Outcome
Plasma levels of asymmetric dimethylarginine (ADMA) and monomethylarginine (LMMA)surrogate
High-dose statin therapy effectively lowers LDL cholesterol but does not influence plasma concentrations of the endogenous nitric oxide synthase inhibitors ADMA or LMMA.
Cite This Study
Päivä et al. (2003) conducted an RCT in Mild hypercholesterolemia (n=48). High-dose statin treatment (simvastatin or atorvastatin) vs. Placebo was evaluated on Plasma levels of ADMA and LMMA. High-dose statin treatment with simvastatin or atorvastatin effectively lowered LDL cholesterol but did not change plasma concentrations of ADMA or LMMA.