Key result
Severe OSAHS was associated with significantly lower circulating adiponectin levels after wake-up compared to controls (5.2 vs 8.5 microg/ml, P<0.01), a nocturnal drop that was improved by nCPAP.
Why the study?
Does one-night nCPAP improve the nocturnal reduction of serum adiponectin levels in patients with severe OSAHS?
Observational (n=93)
Does one-night nCPAP improve the nocturnal reduction of serum adiponectin levels in patients with severe OSAHS?
Absolute Event Rate: 5.2% vs 8.5%
p-value: p=< 0.01
Severe OSAHS is associated with a nocturnal reduction in antiatherosclerotic adiponectin levels due to hypoxic stress, which can be partially reversed by one night of nCPAP.
May signal heightened overnight CV vulnerability in severe OSAHS; hypothesis-generating for hypoxia effects on adiponectin.
Previous reports demonstrated that adiponectin has antiatherosclerotic properties. Obstructive sleep apnea-hypopnea syndrome (OSAHS) is reported to exacerbate atherosclerotic diseases. We investigated nocturnal alternation of serum adiponectin levels before sleep and after wake-up in OSAHS patients and the effect of sustained hypoxia on adiponectin in vivo and in vitro. We measured serum adiponectin concentrations in 75 OSAHS patients and 18 control subjects before sleep and after wake-up and examined the effect of one-night nasal continuous positive airway pressure (nCPAP) on adiponectin in 24 severe OSAHS patients. We investigated the effects of hypoxia on adiponectin in mice and cultured adipocytes with a sustained hypoxia model. Circulating adiponectin levels before sleep and after wake-up were lower in severe OSAHS patients than in control subjects [before sleep: 5.9 +/- 2.9 vs. 8.8 +/- 5.6 microg/ml (P < 0.05); after wake-up: 5.2 +/- 2.6 vs. 8.5 +/- 5.5 microg/ml (P < 0.01), respectively; means +/- SD]. Serum adiponectin levels diminished significantly during sleep in severe OSAHS patients (P < 0.0001), but one-night nCPAP improved the drop in serum adiponectin levels [-18.4 +/- 13.4% vs. -10.4 +/- 12.4% (P < 0.05)]. In C57BL/6J mice and 3T3-L1 adipocytes, hypoxic exposure decreased adiponectin concentrations by inhibiting adiponectin regulatory mechanisms at secretion and transcriptional levels. The present study demonstrates nocturnal reduction in circulating adiponectin levels in severe OSAHS. Our experimental studies showed that hypoxic stress induced adiponectin dysregulation at transcriptional and posttranscriptional levels. Hypoxic stress is, at least partly, responsible for the reduction of serum adiponectin in severe OSAHS. Nocturnal reduction in adiponectin in severe OSAHS may be an important risk for cardiovascular events or other OSAHS-related diseases during sleep.
No takes yet. Share an insight, caveat, or question.
Nakagawa et al. (2008) conducted an observational in Obstructive sleep apnea-hypopnea syndrome (OSAHS) (n=93). Severe obstructive sleep apnea-hypopnea syndrome (OSAHS) vs. Control subjects was evaluated on Circulating adiponectin levels after wake-up (microg/ml) (p=< 0.01). Severe OSAHS was associated with significantly lower circulating adiponectin levels after wake-up compared to controls (5.2 vs 8.5 microg/ml, P<0.01), a nocturnal drop that was improved by nCPAP.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: