Key result
Aspirin therapy at 1.2 g/day or 3.6 g/day prolonged bleeding time but did not increase perioperative blood loss compared with historical controls.
Why the study?
Does aspirin increase bleeding time and perioperative blood loss in patients undergoing total hip replacement?
Population
129 patients undergoing total hip replacement
Comparison
Aspirin 300 mg four times a day or 900 mg four… vs Historical control subjects
Design
Cohort
Follow-up
Three to five days
Authors
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Dose-independent bleeding time prolongation with aspirin post-hip replacement; leaves open optimal dosing for thromboprophylaxis versus bleeding risk.
Cohort (n=129)
Does aspirin increase bleeding time and perioperative blood loss in patients undergoing total hip replacement?
Aspirin therapy at 1.2 g/day or 3.6 g/day prolongs bleeding time but does not appear to increase perioperative blood loss in patients undergoing total hip replacement.
Philip C. Amrein (1981) conducted a cohort in Total hip replacement (n=129). Aspirin vs. Historical control subjects was evaluated on Bleeding time and perioperative blood loss. Aspirin therapy at 1.2 g/day or 3.6 g/day prolonged bleeding time but did not increase perioperative blood loss compared with historical controls.
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