Key result
In the oxygenated isolated guinea-pig heart, the transmethylation pathway is an important O2-independent source of adenosine, producing approximately 0.98 to 1.12 nmol/min per g.
Population
Isolated guinea-pig hearts
Design
Preclinical
Authors
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Supports adenosine research models in normoxia; leaves open translation to human ischemia or in vivo settings.
In the isolated guinea-pig heart, the transmethylation pathway is a major, oxygen-independent intracellular source of adenosine.
Lloyd et al. (1988) studied this question. Normoxic and hypoxic perfusion was evaluated on Rate of transmethylation (adenosine production). In the oxygenated isolated guinea-pig heart, the transmethylation pathway is an important O2-independent source of adenosine, producing approximately 0.98 to 1.12 nmol/min per g.
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