Population
Isolated guinea pig hearts and human erythrocytes
Design
Preclinical
Authors
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Supports intracellular adenosine formation in hypoxia; hypothesis-generating for nucleoside transport targeting, requires human validation.
In the hypoxic heart, adenosine is predominantly formed intracellularly and its release requires transport across the sarcolemma membrane, rather than being formed by ecto-5'-nucleotidase.
Schütz et al. (1981) studied this question.
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