October 1, 1991British Journal of PharmacologyOpen Access

Adenosine receptors and nucleoside transport sites in cardiac cells

View Full Paper

Ask AI

Bookmark

Population

Guinea-pig heart cells (cardiac myocytes, atrioventricular conduction cells, and coronary endothelial cells)

Design

Preclinical

Authors

FPFiona E. ParkinsonUniversity of Manitoba ACAlexander S. ClanachanGeneral / Preventive / Lipids

Discussion

Member takes

Implication

May underlie adenosine's dromotropic selectivity in animal hearts; leaves open human receptor distribution and therapeutic relevance.

Structured PICO

Population

Guinea-pig heart cells (cardiac myocytes, atrioventricular conduction cells, and coronary endothelial cells)

Intervention

Autoradiographical analysis of binding of A1 selective antagonist [3H]-DPCPX and nucleoside transport ligand [3H]-NBMPR

Outcome

Density of adenosine A1 receptors and nucleoside transport (NT) sites across different cardiac cell typessurrogate

The pronounced dromotropic effect of adenosine correlates with a significantly higher density of adenosine A1 receptors in atrioventricular conduction cells compared to myocytes.

Cite This Study

Parkinson et al. (1991) studied this question.

synapsesocial.com/papers/6a762fe1b515f78917fbe1ca https://doi.org/10.1111/j.1476-5381.1991.tb12442.x

View Full Paper

Ask AI

Bookmark

Adenosine receptors and nucleoside transport sites in cardiac cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine receptors and nucleoside transport sites in cardiac cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider