Key result
BVDV-1b was the most prevalent subgenotype in the United States, whereas BVDV-1c was most prevalent in Australia, with detectable antigenic differences between subgenotypes.
Regional differences in BVDV subgenotype prevalence and their antigenic variations suggest that vaccine efficacy may be improved by targeting regionally prevalent subgenotypes.
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Regional BVDV subgenotype differences may affect vaccine cross-protection; leaves open whether tailored vaccines improve efficacy in cattle.
Ridpath et al. (2010) studied Bovine viral diarrhea virus (BVDV) (n=865). BVDV subgenotypes was evaluated on Prevalence of BVDV subgenotypes and antigenic differences. BVDV-1b was the most prevalent subgenotype in the United States, whereas BVDV-1c was most prevalent in Australia, with detectable antigenic differences between subgenotypes.
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