Key result
Multivariate analysis of virus neutralization titers demonstrated clustering patterns among BVDV isolates, revealing antigenic relatedness across different subgenotypes within the same species.
Why the study?
Genetic sequencing is unreliable for defining antigenic relationships and virus neutralization assay data can be difficult to discern for BVDV isolates within the same species.
Population
Seven vaccine strains and 23 BVDV field isolates from Switzerland, Italy, Brazil, and the UK
Comparison
Polyclonal sera against six vaccine strains tested across seven vaccine strains and 23 field isolates
Design
In vitro neutralization assay with principal component analysis
Authors
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Multivariate VN analysis clarifies antigenic divergence among BVDV isolates; extends evidence that subgenotype assignment does not predict relatedness.
Multivariate analysis of virus neutralization assays can effectively characterize antigenic relationships among BVDV isolates, potentially aiding in vaccine composition for BVDV control programs.
Mósena et al. (2021) studied Bovine viral diarrhea virus (BVDV). Multivariate analysis (Principal Component Analysis) of virus neutralization assays was evaluated on Antigenic relationships and clustering patterns. Multivariate analysis of virus neutralization titers demonstrated clustering patterns among BVDV isolates, revealing antigenic relatedness across different subgenotypes within the same species.
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