Key result
High red cell distribution width was associated with a 30% increased risk of incident cancer in men (HR 1.30) compared to the lowest quartile, with a similar risk increase observed in post-menopausal women.
Why the study?
Does red cell distribution width impact the future risk of cancer and all-cause mortality among cancer patients?
Cohort (n=25,383)
No
Does red cell distribution width impact the future risk of cancer and all-cause mortality among cancer patients?
Hazard Ratio: 1.3 (95% CI 1.07–1.59)
Absolute Event Rate: 13.89% vs 3.64%
Does not support changing cancer screening; leaves open RDW value in risk stratification models.
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Ellingsen et al. (2015) conducted a cohort in Incident cancer and all-cause mortality (n=25,383). High red cell distribution width (RDW) vs. Lowest RDW quartile was evaluated on Incident cancer in men (HR 1.30, 95% CI 1.07-1.59). High red cell distribution width was associated with a 30% increased risk of incident cancer in men (HR 1.30) compared to the lowest quartile, with a similar risk increase observed in post-menopausal women.
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