Clinical assessment and molecular mechanism of the upregulation of Toll-like receptor 2 (TLR2) in myocardial infarction

Figures

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  Fig. 1. The screening process of all eligible studies of the expression levels of Toll-Like Receptor 2 (TLR2) in myocardial infarction (MI)

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  Fig. 2. The expression levels of TLR2 between the MI and control group from high throughput datasets. A GSE19339, B GSE29532, C GSE34198, D GSE48060, E GSE60993, F GSE66360, G GSE97320, H GSE109048, I GSE141512

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  Fig. 3. Comprehensive TLR2 expression levels of MI after the omission of GSE34198. A Forest plot of TLR2 expression, B sensitivity analysis, C Begg's test, D. Egger's test

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  Fig. 4. Potential differentiating ability of TLR2 overexpression in MI. A sROC curve, B Sensitivity and specificity, C Positive and Negative likelihood ratio, D Odds ratio

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  Fig. 5. scRNA-seq analysis process of GSE145154. A Uniform manifold approximation and projection (UMAP) distribution of 22 annotated cell types in MI tissues. B Distribution of TLR2 expression in cell clusters of MI tissues. C UMAP distribution of 11 annotated cell types in MI tissues. D KEGG pathway [25–27] analysis of Myeloid cells in MI tissues. E Mcode module of upregulated genes on Myeloid cells in MI tissues.

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  Fig. 6. Trajectory analysis of Myeloid cells in MI tissue. A The two-dimensional trajectory distribution map of cluster annotated on Myeloid cells. B The two-dimensional distribution map of state shows the trajectory results of Myeloid cells. C Display diagram of cell development timing score calculated according to development trajectory analysis. D The dynamic changes of the expression level of TLR2 during development

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  Fig. 7. CellPhoneDB (Release v2.1.7) [28] and PISCES analysis of GSE145154. A Network diagram of cells expressing TLR2. B Heatmap of interaction level of 6 kinds of cells expressing TLR2. C K-nearest neighbor (KNN) graph by evaluating viper similarity distance. D Uniform manifold approximation and projection (UMAP) distribution of Viper clustering. E Proteins inferring differentially expressed on 5 clusters. F GO function enrichment analysis of differentially expressed proteins