Key result
TLR-2 knockout mice had a significantly higher survival rate 4 weeks after myocardial infarction compared to wild-type mice (65% vs 43%, P<0.03), alongside reduced myocardial fibrosis.
Why the study?
Does TLR-2 knockout improve survival and attenuate ventricular remodeling after myocardial infarction in mice?
Population
Wild-type mice and TLR-2-knockout mice with myocardial infarction induced by surgical left anterior…
Comparison
TLR-2 knockout (genetic deletion) vs Wild-type (WT) mice
Design
Preclinical
Follow-up
4 weeks
Authors
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Should not change post-MI care; hypothesis-generating for TLR-2 inhibition in remodeling.
Does TLR-2 knockout improve survival and attenuate ventricular remodeling after myocardial infarction in mice?
Absolute Event Rate: 65% vs 43%
p-value: p=<0.03
Genetic deletion of TLR-2 improves survival and attenuates adverse ventricular remodeling following myocardial infarction in mice.
Shishido et al. (2003) studied Myocardial infarction. TLR-2 knockout vs. Wild-type mice was evaluated on Survival rate at 4 weeks (p=<0.03). TLR-2 knockout mice had a significantly higher survival rate 4 weeks after myocardial infarction compared to wild-type mice (65% vs 43%, P<0.03), alongside reduced myocardial fibrosis.
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