Key result
angptl4 deficiency in mice altered endothelial junction organization and pericyte coverage, leading to impaired angiogenesis and strongly inhibited pathological neovascularization.
ANGPTL4 plays a critical role in regulating endothelial cell junction organization, pericyte coverage, and vascular permeability during both developmental and pathological retinal angiogenesis.
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Preclinical ANGPTL4 findings in retinopathy models warrant caution before trials; leaves open human translation and therapeutic targeting.
Perdiguero et al. (2011) studied proliferative retinopathies. angptl4 deficiency was evaluated on angiogenesis, vascular permeability, and pathological neovascularization. angptl4 deficiency in mice altered endothelial junction organization and pericyte coverage, leading to impaired angiogenesis and strongly inhibited pathological neovascularization.
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