Key result
Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine implicated in the pathogenesis of ischemic retinopathies, with potential applications as a diagnostic biomarker and therapeutic target.
This review highlights the role of ANGPTL4 in the pathogenesis of ischemic retinopathies and its potential as a biomarker and therapeutic target.
ANGPTL4 targeting in ischemic retinopathies should not yet change practice; leaves open its precise role amid conflicting mechanisms.
Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation. Dysregulations in these responses contribute to the pathogenesis of ischemic retinopathies such as diabetic retinopathy (DR), age-related macular degeneration (AMD), retinal vein occlusion, and sickle cell retinopathy (SCR). However, the role of ANGPTL4 in these diseases remains controversial. Here, we summarize the functional mechanisms of ANGPTL4 in several diseases. We highlight original studies that provide detailed data about the mechanisms of action for ANGPTL4, its applications as a diagnostic or prognostic biomarker, and its use as a potential therapeutic target. Taken together, the discussions in this review will help us gain a better understanding of the molecular mechanisms by which ANGPTL4 functions in eye disease and will provide directions for future research.
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Yang et al. (2018) conducted a review in Ischemic retinopathies (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, sickle cell retinopathy). Angiopoietin-like protein 4 (ANGPTL4) was evaluated. Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine implicated in the pathogenesis of ischemic retinopathies, with potential applications as a diagnostic biomarker and therapeutic target.
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