Key result
Higher baseline levels of interleukin-6 were consistently associated with higher intra-individual variability in systolic, diastolic, and pulse pressure in older adults at high cardiovascular risk.
Why the study?
Are biological markers (such as interleukin-6) associated with visit-to-visit blood pressure variability in elderly patients at high risk of cardiovascular disease?
Observational (n=3,794)
Are biological markers (such as interleukin-6) associated with visit-to-visit blood pressure variability in elderly patients at high risk of cardiovascular disease?
Baseline inflammation, indicated by higher interleukin-6 levels, is associated with increased visit-to-visit blood pressure variability in elderly patients at high cardiovascular risk.
Inflammation marker ties to BP variability; leaves open causal mechanisms and outcome impact in elderly at CVD risk.
BACKGROUND: Visit-to-visit variability in blood pressure is an independent predictor of cardiovascular disease. This study investigates biological correlates of intra-individual variability in blood pressure in older persons. METHODS: Nested observational study within the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) among 3,794 male and female participants (range 70-82 years) with a history of, or risk factors for cardiovascular disease. Individual visit-to-visit variability in systolic and diastolic blood pressure and pulse pressure (expressed as 1 SD in mm Hg) was assessed using nine measurements over 2 years. Correlates of higher visit-to-visit variability were examined at baseline, including markers of inflammation, endothelial function, renal function and glucose homeostasis. RESULTS: Over the first 2 years, the mean intra-individual variability (1 SD) was 14.4mm Hg for systolic blood pressure, 7.7mm Hg for diastolic blood pressure, and 12.6mm Hg for pulse pressure. After multivariate adjustment a higher level of interleukin-6 at baseline was consistently associated with higher intra-individual variability of blood pressure, including systolic, diastolic, and pulse pressure. Markers of endothelial function (Von Willebrand factor, tissue plasminogen activator), renal function (glomerular filtration rate) and glucose homeostasis (blood glucose, homeostatic model assessment index) were not or to a minor extent associated with blood pressure variability. CONCLUSION: In an elderly population at risk of cardiovascular disease, inflammation (as evidenced by higher levels of interleukin-6) is associated with higher intra-individual variability in systolic, diastolic, and pulse pressure.
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Poortvliet et al. (2014) conducted an observational in History of, or risk factors for cardiovascular disease (n=3,794). Higher baseline levels of interleukin-6 was evaluated on Intra-individual visit-to-visit variability in systolic, diastolic, and pulse pressure. Higher baseline levels of interleukin-6 were consistently associated with higher intra-individual variability in systolic, diastolic, and pulse pressure in older adults at high cardiovascular risk.
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