Key result
Hypertension with left ventricular hypertrophy was associated with a lower transmitral peak E/A ratio (0.77) compared to hypertension without hypertrophy (1.01) and normotensive subjects (1.37; P<0.00001).
Why the study?
Does left ventricular hypertrophy in hypertensive patients affect regional diastolic function as assessed by Doppler tissue imaging?
Population
50 men, including 10 normotensive subjects, 20 hypertensive patients without left ventricular hypertrophy…
Comparison
Assessment of regional diastolic function using… vs Comparison between normotensive subjects…
Design
Cross-sectional
Authors
Loading...
Supports LVH-diastolic impairment link in hypertension; leaves open prognostic and therapeutic implications pending prospective data.
Observational (n=50)
Does left ventricular hypertrophy in hypertensive patients affect regional diastolic function as assessed by Doppler tissue imaging?
Absolute Event Rate: 0.77% vs 1.37%
p-value: p=< 0.00001
Doppler tissue imaging reveals that diastolic dysfunction is uniform in hypertensive patients without hypertrophy, but disproportionately affects the basal septum in those with left ventricular hypertrophy.
Galderisi et al. (1999) conducted an observational in Hypertension with or without left ventricular hypertrophy (n=50). Hypertension with left ventricular hypertrophy vs. Normotensive subjects and hypertensive patients without hypertrophy was evaluated on Transmitral peak E/A ratio (p=< 0.00001). Hypertension with left ventricular hypertrophy was associated with a lower transmitral peak E/A ratio (0.77) compared to hypertension without hypertrophy (1.01) and normotensive subjects (1.37; P<0.00001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: