Key result
Diabetes in patients with dilated cardiomyopathy was associated with higher cardiac mortality and heart failure mortality, but not sudden cardiac death.
Why the study?
Does diabetes affect ventricular repolarization and sudden cardiac death risk in patients with dilated cardiomyopathy?
Cohort (n=132)
Does diabetes affect ventricular repolarization and sudden cardiac death risk in patients with dilated cardiomyopathy?
In patients with dilated cardiomyopathy, diabetes increases the risk of heart failure mortality but does not affect ventricular repolarization or the risk of sudden cardiac death.
Answers are grounded in this paper and cite their sources.
Diabetes may alter repolarization in DCM; leaves open independent SCD risk prediction.
BACKGROUND: We studied the effects of diabetes on ventricular repolarization parameters and sudden cardiac death in patients with dilated cardiomyopathy (DCM). METHODS: We enrolled 132 consecutive patients in New York Heart Association (NYHA) heart failure functional classes II or III and left ventricular ejection fraction <40% without evidence of coronary artery disease. In 45 patients (34%), diabetes was diagnosed according to standard criteria (study group), and the remaining 87 (66%) had no diabetes (controls). All patients underwent a 5-minute high-resolution electrocardiogram recording for determination of QT variability (QTV) index and were followed for 1 year thereafter. RESULTS: At baseline, the two groups did not differ in age, gender, left ventricular ejection fraction, NYHA functional class, or plasma brain natriuretic peptide levels. Similarly, QTV index did not differ between the study group (-0.51 +/- 0.55) and controls (-0.48 +/- 0.51; P = 0.48). During follow-up, 18 patients (14%) died of cardiac causes. Of the 18 deaths, eight were attributed to heart failure, and 10 to sudden cardiac death. Mortality was higher in the study group (10/45, 20%) than in controls (8/87, 10%) (P = 0.03). The same was true of the heart failure mortality (6/45 [13%] vs 2/87 [2%], P = 0.01), but not of the sudden cardiac death rate (3/45 [7%] vs 7/87 [8%], P = 0.78). By multiple variable analyses, diabetes predicted total and heart failure mortality, and a high QTV predicted sudden cardiac death. CONCLUSIONS: Diabetes appears to increase the risk of heart failure in patients with DCM without affecting ventricular repolarization parameters and sudden cardiac death risk.
No takes yet. Share an insight, caveat, or question.
Vrtovec et al. (2009) conducted a cohort in Dilated cardiomyopathy (n=132). Diabetes vs. No diabetes was evaluated on Cardiac mortality (p=0.03). Diabetes in patients with dilated cardiomyopathy was associated with higher cardiac mortality and heart failure mortality, but not sudden cardiac death.
Synapse has enriched 10 related papers. Consider them for comparative context: