Key result
Diabetes linked to ~325% higher MACE and mortality risk, especially with LV dysfunction.
Why the study?
The role of diabetes in the long-term prognosis of patients with ischemic cardiomyopathy and severe left ventricular dysfunction was unknown.
Does the presence of diabetes mellitus worsen long-term outcomes in patients with ischemic cardiomyopathy?
Cohort (n=918)
No
Does the presence of diabetes mellitus worsen long-term outcomes in patients with ischemic cardiomyopathy?
Hazard Ratio: 4.25 (95% CI 3.62–5.65)
p-value: p=<0.001
In patients with multivessel coronary artery disease, the combination of diabetes and ventricular dysfunction is associated with significantly higher long-term mortality than either condition alone.
No takes yet. Share an insight, caveat, or question.
May warrant closer monitoring in diabetic patients with ischemic cardiomyopathy and LV dysfunction; leaves open whether targeted interventions improve outcomes.
Hueb et al. (2018) conducted a cohort in Ischemic cardiomyopathy and stable multivessel coronary artery disease (n=918). Diabetes mellitus vs. Patients without diabetes was evaluated on Major adverse cardiac events (overall mortality, nonfatal myocardial infarction, stroke, or refractory angina requiring revascularization) (HR 4.25, 95% CI 3.62-5.65, p=<0.001). The presence of diabetes mellitus significantly increased the risk of major adverse cardiac events (HR 4.25) and overall mortality, particularly in patients with left ventricular dysfunction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: