Key result
Diabetes mellitus did not affect 5-year all-cause mortality but increased composite adverse events in patients with ischemic heart disease and left ventricular dysfunction undergoing CABG.
Why the study?
Few studies have focused on the controversial effect of diabetes mellitus on long-term outcomes in patients with left ventricular dysfunction undergoing surgical revascularization.
Does diabetes mellitus worsen long-term outcomes in patients with ischemic heart disease and left ventricular dysfunction undergoing CABG?
Observational (n=346)
No
Does diabetes mellitus worsen long-term outcomes in patients with ischemic heart disease and left ventricular dysfunction undergoing CABG?
In patients with ischemic heart disease and left ventricular dysfunction undergoing CABG, diabetes mellitus significantly increases the risk of long-term major adverse cardiovascular and cerebrovascular events, although it does not significantly affect 5-year all-cause mortality.
Answers are grounded in this paper and cite their sources.
DM-associated MACCE increase after CABG in IHD with LV dysfunction warrants closer surveillance; leaves open optimal risk modification strategies.
Background Diabetes mellitus (DM) is an important risk factor in the long-term outcomes of surgical revascularization. However, few studies have focused on patients with left ventricular dysfunction (LVD) and DM, and the results are controversial. This study aimed to evaluate the effect of DM on the long-term outcomes of patients with ischemic heart disease (IHD) and LVD undergoing coronary artery bypass grafting(CABG). Methods In this propensity-matched study, patients with IHD and LVD who underwent CABG in our hospital from January 2007 to December 2017 were enrolled. The patients were divided into two groups according to whether they had DM. The primary endpoint was all-cause death, and the secondary endpoint was a composite of all-cause death, stroke, recurrent myocardial infarction, and re-revascularization. Results There was no significant difference in all-cause mortality between the two groups(5.78%vs.4.05%,P=0.216). The incidence of main adverse cardiovascular and cerebrovascular events(MACCE) in the secondary endpoint was significantly higher in the DM group than in the non-DM group (10.40% vs. 8.09%, P=0.023).Conclusions DM can negatively affect the long-term outcome of patients with IHD and LVD undergoing CABG by significantly increasing the overall incidence of MACCE, though the long-term survival doesn’t show significant difference between the DM and non-DM patients.
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liu et al. (2020) conducted an observational in Ischemic heart disease and left ventricular dysfunction (n=346). Diabetes mellitus vs. No diabetes mellitus was evaluated on All-cause death at 5 years (p=0.216). Diabetes mellitus did not affect 5-year all-cause mortality but increased composite adverse events in patients with ischemic heart disease and left ventricular dysfunction undergoing CABG.
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