November 8, 2004Archives of Internal Medicine
Impact of Diabetes on Mortality in Patients With Myocardial Infarction and Left Ventricular Dysfunction
Why the study?
Does diabetes increase the risk of mortality and cardiovascular events in patients who survived MI with left ventricular dysfunction?
Population
2,231 patients following acute myocardial infarction with left ventricular dysfunction
Comparison
History of diabetes (exposure) vs No history of diabetes
Design
Cohort, randomized, double-blind, placebo-controlled
Follow-up
2 to 5 years (mean, 3.5 years)
Authors
Discussion
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Member takes
Implication
May identify high-risk diabetic survivors of MI with LV dysfunction for closer monitoring; leaves open whether targeted interventions improve outcomes.
Structured PICO
Does diabetes increase the risk of mortality and cardiovascular events in patients who survived MI with left ventricular dysfunction?
P
Population
2,231 patients following acute myocardial infarction with left ventricular dysfunction (ejection fraction ≤ 40%)
I
Intervention
History of diabetes (exposure)
C
Comparator
No history of diabetes
O
Outcome
Total mortality and major cardiovascular eventshard clinical
Diabetes, particularly when requiring insulin, independently increases the risk of mortality and cardiovascular events in survivors of MI with left ventricular dysfunction.
Cite This Study
Murcia et al. (2004) studied this question.