Key result
Diabetes was associated with a higher risk of all-cause mortality (adjusted HR 1.37; 95% CI 1.25-1.51) and death or heart failure hospitalization across the spectrum of LVEF in post-MI patients.
Why the study?
Does diabetes increase the risk of adverse outcomes across the spectrum of LVEF in patients with high-risk myocardial infarction?
Cohort (n=11,325)
Yes
Does diabetes increase the risk of adverse outcomes across the spectrum of LVEF in patients with high-risk myocardial infarction?
Effect estimate: adjusted HR 1.37 (95% CI 1.25-1.51)
Diabetes is associated with a higher risk of death or HF hospitalization across the spectrum of LVEF in high-risk post-MI patients, and attenuates the protective effect of higher LVEF.
No takes yet. Share an insight, caveat, or question.
Diabetes may blunt LVEF protection post-MI; extends evidence on consistent risk across LVEF but requires prospective validation.
Shah et al. (2010) conducted a cohort in Acute myocardial infarction complicated by heart failure, systolic dysfunction, or both (n=11,325). Diabetes vs. No diabetes was evaluated on All-cause mortality (adjusted HR 1.37, 95% CI 1.25-1.51). Diabetes was associated with a higher risk of all-cause mortality (adjusted HR 1.37; 95% CI 1.25-1.51) and death or heart failure hospitalization across the spectrum of LVEF in post-MI patients.
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