Why the study?
Does an automatic telephone reminder survey improve therapy compliance and clinical surrogate markers (BP, lipids) in ambulatory cardiac patients?
Cohort (n=604)
Open-label
Yes
Does an automatic telephone reminder survey improve therapy compliance and clinical surrogate markers (BP, lipids) in ambulatory cardiac patients?
Effect estimate: Reduction of 27.9% vs 12.0%
Absolute Event Rate: -27.9% vs -12%
p-value: p=0.001
Automated telephone reminders added to usual care can significantly improve lipid parameter control and therapy adherence in ambulatory patients with high cardiovascular risk.
Aim. To assess the impact of automatic telephone survey with a differentiated reminder text, as well as of the survey combination with the self-control dairy, on the compliance with lipid-lowering and antihypertensive therapy and on therapy effectiveness during the longterm ambulatory follow-up. Material and methods. The study included 604 patients: 323 individuals with high or very high cardiovascular risk levels by SCORE scale and 281 participants with coronary heart disease (CHD). The patients were divided into two groups, according to their agreement to participate in the automatic telephone reminder survey (“Survey” and “Refusal”). All participants were also given a self-control diary. At baseline and one year later, the patients underwent general clinical examination, office blood pressure (BP) measurement, blood biochemistry assessment, and the measurement of therapy compliance (Morisky-Green test), anxiety, and depression levels (HADS scale). Results. The reduction in diastolic BP levels was significantly larger in the Survey group (p=0,04). This group also demonstrated a significantly larger decrease in the levels of total cholesterol (TCH) (p=0,0003) and low-density lipoprotein cholesterol (LDL-CH) (p=0,001), as well as a significantly larger increase in the levels of high-density lipoprotein cholesterol (HDL-CH) (p=0,04). The therapy compliance, assessed by the Morisky-Green test, improved in both groups; however, among CHD patients, a significant improvement was observed only in the Survey group (p<0,00001). The percentage of patients submitting their self-control diaries was higher for the Survey group (p<0,0001). Conclusion. The automatic telephone reminder method provides an opportunity to significantly increase the therapy compliance.
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Агеев et al. (2012) conducted a cohort in High cardiovascular risk or Coronary Heart Disease (n=604). Automatic telephone reminder survey vs. Self-control diary only (refusal group) was evaluated on Low-density lipoprotein cholesterol (LDL-C) percent reduction at 1 year (Reduction of 27.9% vs 12.0%, p=0.001).
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