Key result
pH-sensitive chitosan hydrogels demonstrated biocompatibility, supporting 31% and 36% cell growth of human bone marrow mesenchymal stem cells over 14 days for WH and MH samples, respectively.
Population
Human Bone Marrow Mesenchymal Stem Cells (hBMSCs) and human Adipose Mesenchymal Stem Cells (hADSCs) in vitro
Design
Preclinical
Follow-up
up to 21 days (in vitro)
Authors
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Hypothesis-generating for injectable myocardial scaffolds; leaves open in vivo efficacy post-MI.
pH-sensitive chitosan hydrogels demonstrate favorable in vitro biocompatibility and structural properties, suggesting potential utility as injectable scaffolds for myocardial regeneration.
Alimirzaei et al. (2017) studied Myocardial infarction. pH-sensitive chitosan hydrogel (WH and MH samples) was evaluated on Cell growth of human Bone Marrow Mesenchymal Stem Cells (hBMSCs) at 14 days. pH-sensitive chitosan hydrogels demonstrated biocompatibility, supporting 31% and 36% cell growth of human bone marrow mesenchymal stem cells over 14 days for WH and MH samples, respectively.
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