Key result
Adenosine analogues N6-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine inhibit cardiac adenylate cyclase in a concentration-dependent manner in guinea-pig myocardium.
Demonstrates the presence of inhibitory type (R1 or A1) adenosine receptors in guinea-pig myocardium that mediate adenylate cyclase inhibition.
Findings from guinea-pig myocardium warrant no clinical change; leaves open translation of A1 receptor effects to human cardiac disease.
Adenosine analogues N6-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine inhibit cardiac adenylate cyclase in a concentration dependent manner. Inhibition of adenylate cyclase required the presence of guanosine-triphosphate and Mg2+ ion. The concentration of Na+ ion was critically important: maximal inhibition was observed at 50 mmol/l Na+. 8-Phenyltheophylline and isobutylmethylxanthine antagonized the inhibition of adenylate cyclase mediated by adenosine analogues. Adenosine receptors of the inhibitory type (R1 or A1) are present in guinea-pig myocardium and may mediate some actions of adenosine.
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Leung et al. (1983) studied this question. Adenosine analogues (N6-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine) was evaluated on Inhibition of cardiac adenylate cyclase. Adenosine analogues N6-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine inhibit cardiac adenylate cyclase in a concentration-dependent manner in guinea-pig myocardium.
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