Key result
Ultrasound controlled attenuation parameters combined with ALT demonstrated high diagnostic accuracy for MASLD, yielding AUROCs of 0.776, 0.924, and 0.997 (P<0.05).
Why the study?
To explore the diagnostic value of controlled attenuation parameters combined with serum biochemical indicators for metabolic dysfunction-associated steatotic liver disease.
Does the combination of ultrasound controlled attenuation parameters and serum indicators accurately diagnose MASLD compared to CT liver/spleen ratio?
Case-Control (n=200)
No
Does the combination of ultrasound controlled attenuation parameters and serum indicators accurately diagnose MASLD compared to CT liver/spleen ratio?
Effect estimate: AUROC 0.823
p-value: p=<0.05
Ultrasound controlled attenuation parameters combined with ALT and TG demonstrate near-perfect diagnostic accuracy for MASLD, offering a highly effective non-invasive diagnostic tool.
May support combined CAP-biochemical assessment for MASLD diagnosis; leaves open need for prospective validation before clinical adoption.
Objective To explore the diagnostic value of controlled attenuation parameters combined with serum biochemical indicators for metabolic dysfunction–associated steatotic liver disease (MASLD). Methods A total of 145 patients with MASLD who visited our hospital from January 2023 to June 2024 were included. 55 healthy subjects were used as controls. The ROC curve was drawn with the CT liver/spleen ratio as the diagnostic standard, and the area under the curve was calculated to evaluate the diagnostic value of fat attenuation parameters for MASLD. Results The best cut-off value of the fat attenuation parameter for diagnosing fatty liver was 262.5 dB/m (AUROC = 0.823, sensitivity = 0.820, specificity = 0.701, P < 0.05). The best cut-off values of fat attenuation parameters for diagnosing mild, moderate, and severe fatty liver were 225.5 dB/m, 267.5 dB/m, and 289.5 dB/m, respectively, with AUROC of 0.440, 0.665, and 0.808, all P < 0.05. The combination of fat attenuation parameter with alanine aminotransferase or triglyceride can enhance the diagnostic value of MASLD, and the diagnostic efficacy of fat attenuation parameter combined with ALT was substantially higher, the AUROC was 0.776, 0.924, and 0.997, all P < 0.05. Conclusion Ultrasound controlled attenuation parameters combined with ALT and TG have near-perfect diagnostic accuracy. for MASLD.
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Liu et al. (2025) conducted a case-control in Metabolic dysfunction-associated steatotic liver disease (MASLD) (n=200). Ultrasound controlled attenuation parameters combined with ALT and TG vs. CT liver/spleen ratio (reference standard) was evaluated on Diagnostic accuracy for fatty liver (AUROC 0.823, p=<0.05). Ultrasound controlled attenuation parameters combined with ALT demonstrated high diagnostic accuracy for MASLD, yielding AUROCs of 0.776, 0.924, and 0.997 (P<0.05).
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