Ideal cardiovascular health, biomarkers, and coronary artery disease in persons with HIV
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Key result
Among people with HIV, poor cardiovascular health was associated with a higher prevalence of coronary plaque (present in 49% overall), vulnerable features (23%), and calcification (35%).
Why the study?
To investigate relationships between Life's Simple 7, an assessment of cardiovascular health, and coronary plaque among people with HIV.
Is cardiovascular health as measured by Life's Simple 7 associated with coronary plaque and inflammatory biomarkers in people with HIV?
Population
735 ART-treated people with HIV enrolled in REPRIEVE
Comparison
Cardiovascular health categorized as poor vs intermediate vs ideal by Life's Simple 7
Design
Cross-sectional study
Authors
Discussion
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Member takes
Implication
Poor LS7 links to higher plaque prevalence in PWH independent of ASCVD risk; leaves open whether optimizing CVH prevents atherosclerosis.
Study Design
Type
Cross-Sectional (n=735)
Structured PICO
Is cardiovascular health as measured by Life's Simple 7 associated with coronary plaque and inflammatory biomarkers in people with HIV?
P
Population
735 ART-treated people with HIV (mean age 51, 16% female) enrolled in a primary prevention trial, assessed for cardiovascular health and coronary plaque.
E
Exposure
Life's Simple 7 (LS7) cardiovascular health assessment
O
Outcome
Coronary plaque presence, vulnerable plaque features, noncalcified plaque, and coronary artery calcium score >0 assessed by coronary computed tomography angiographysurrogate
In people with HIV, poor cardiovascular health measured by Life's Simple 7 is associated with increased coronary plaque and inflammatory biomarkers, independent of traditional ASCVD risk scores.
Cite This Study
Douglas et al. (2022) conducted a cross-sectional in HIV (n=735). Poor cardiovascular health (Life's Simple 7) vs. Ideal cardiovascular health was evaluated on Coronary plaque presence, vulnerable features, and calcification. Among people with HIV, poor cardiovascular health was associated with a higher prevalence of coronary plaque (present in 49% overall), vulnerable features (23%), and calcification (35%).
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