Key result
Serum uric acid was associated with ECG abnormalities and 5-year mortality secondary to other risk factors in men, but independently in women.
Why the study?
Is serum uric acid an independent risk factor for ECG abnormalities and mortality in men and women?
Observational (n=25,964)
Yes
Is serum uric acid an independent risk factor for ECG abnormalities and mortality in men and women?
Serum uric acid appears to be an independent risk factor for cardiovascular mortality and ECG abnormalities in women, but its association in men is confounded by other risk factors.
Observational uric acid–ECG and mortality associations remain hypothesis-generating; randomized data needed before any clinical inference.
The association between serum uric acid and the prevalence of ECG abnormalities was analyzed for 24.997 employed men and women, white and black, age 18--64 years, from the Chicago Heart Association (CHA) Detection Project in Industry. In addition, the relationships between uric acid and 5-year mortality from all causes, from cardiovascular diseases (CVD), and from coronary heart disease (CHD) were analyzed for 7804 white men and women age 45--64 years from this study and 967 white men age 44--63 years from the Chicago People's Gas Company Study. For men, the association between uric acid and the prevalence of ECG abnormalities and with mortality appear to be secondary to associations between uric acid and other risk factors. For women, however, the associations could not be explained by other risk factors.
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Persky et al. (1979) conducted an observational in Coronary heart disease (n=25,964). Serum uric acid was evaluated on Prevalence of ECG abnormalities and 5-year mortality from all causes, cardiovascular diseases, and coronary heart disease. Serum uric acid was associated with ECG abnormalities and 5-year mortality secondary to other risk factors in men, but independently in women.
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