Demonstration that the atria, ventricles, and lungs each are responsible for a tonic inhibition of the vasomotorcenter in the dog.
Key result
Vagal cooling increased aortic pressure across various isolated cardiopulmonary preparations, demonstrating that afferent vagal nerves from the lungs, atria, and ventricles each tonically inhibit the vasomotor center.
Why the study?
Do the atria, ventricles, and lungs each independently exert tonic inhibition on the vasomotor center in dogs?
Population
Anesthetized dogs subjected to sinoaortic denervation and diaphragmatic vagotomy
Comparison
Interruption of afferent vagal nerve traffic by… vs Baseline state before vagal cooling, and states…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Suggests cardiopulmonary sites mediate tonic vasomotor inhibition in dogs; leaves open human relevance and clinical translation.
Structured PICO
Do the atria, ventricles, and lungs each independently exert tonic inhibition on the vasomotor center in dogs?
P
Population
Anesthetized dogs subjected to sinoaortic denervation and diaphragmatic vagotomy to localize areas of the cardiopulmonary region involved in tonic inhibition of the vasomotor center.
I
Intervention
Interruption of afferent vagal nerve traffic by cooling in the neck under four conditions isolating the lungs, intact heart, atria, or ventricles
C
Comparator
Baseline state before vagal cooling, and states after removing atria or denervating ventricles
O
Outcome
Change in aortic pressure (mm Hg)surrogate
Afferent vagal nerves from the lungs, atria, and ventricles each independently exert tonic inhibition on the vasomotor center in dogs.
Cite This Study
Mancia et al. (1975) studied Anesthetized dogs. Vagal cooling under various isolated cardiopulmonary conditions vs. Baseline / removal of structures was evaluated on Change in aortic pressure. Vagal cooling increased aortic pressure across various isolated cardiopulmonary preparations, demonstrating that afferent vagal nerves from the lungs, atria, and ventricles each tonically inhibit the vasomotor center.