Key result
Receptors in the heart and lungs with nonmedullated vagal afferents exert a tonic inhibition on the vasomotor center, which is inversely related to arterial baroreceptor influence.
Population
Dogs and open-chest cats
Comparison
Vagal cutting/blocking, selective denervation… vs Intact/baseline state
Design
Preclinical
Authors
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May guide vagal therapies in cardiovascular disease; extends canine C-fiber data but leaves open human translation.
Cardiopulmonary receptors with nonmedullated vagal afferents are an important component of the integrated neural control of the circulation, exerting tonic inhibition on sympathetic vasomotor outflow.
Thorén et al. (1976) studied Circulatory control (animal model). Vagal afferent manipulation (cutting, blocking, cooling, stimulation) was evaluated on Vasomotor inhibition and C fiber discharge frequency. Receptors in the heart and lungs with nonmedullated vagal afferents exert a tonic inhibition on the vasomotor center, which is inversely related to arterial baroreceptor influence.
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