Key result
Diabetes was associated with impaired left atrial conduit function, specifically reduced early diastolic strain and strain rate, compared with prediabetic and euglycemic patients with CAD.
Why the study?
Does glycemic state (diabetes or prediabetes) affect left atrial function measured by speckle-tracking echocardiography in patients with coronary artery disease?
Observational (n=205)
Does glycemic state (diabetes or prediabetes) affect left atrial function measured by speckle-tracking echocardiography in patients with coronary artery disease?
In patients with coronary artery disease, diabetes is associated with impaired left atrial conduit function as detected by two-dimensional speckle-tracking echocardiography.
Prediabetes and diabetes are dysglycemic conditions associated with increased cardiovascular risks and subtle myocardial injuries. The aim of our study was to evaluate left atrial (LA) function by two-dimensional speckle-tracking echocardiography in prediabetic and diabetic patients with coronary artery disease (CAD) and compare the results with those in euglycemic patients with CAD. METHODS: The study population comprised 205 consecutive patients with CAD: 104 diabetic, 51 prediabetic, and 50 euglycemic patients. LA function was evaluated with two-dimensional speckle-tracking echocardiography and the longitudinal deformation indices of the LA were measured. RESULTS: Our results showed that early diastolic strain was lower in the diabetic patients than in the prediabetic and euglycemic patients. The absolute value of early diastolic strain rate was reduced in the diabetic patients compared with the euglycemic patients. Late diastolic strain was increased in the diabetic patients compared with the prediabetic and euglycemic patients. The multivariate analysis showed that diabetes was a determinant of early diastolic strain and strain rate, but not late diastolic strain. CONCLUSION: LA conduit function, as evaluated in terms of early diastolic strain and strain rate, was impaired in the diabetic CAD patients compared with the prediabetic and euglycemic CAD patients.
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Hosseinsabet et al. (2017) conducted an observational in Coronary artery disease (n=205). Diabetes and prediabetes vs. Euglycemic patients was evaluated on Left atrial function (longitudinal deformation indices including early and late diastolic strain and strain rate). Diabetes was associated with impaired left atrial conduit function, specifically reduced early diastolic strain and strain rate, compared with prediabetic and euglycemic patients with CAD.
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