Key result
Blockade of non-NMDA and NMDA receptors in the medullary lateral tegmental field reduces basal sympathetic nerve discharge and prevents baroreceptor reflex control in cats.
The medullary lateral tegmental field plays a crucial role in generating and controlling sympathetic nerve discharge and baroreceptor reflexes in feline models.
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Extends cat models of medullary sympathetic control; leaves open human translation.
Data from experiments with single neuron recordings as well as central microinjections of N-methyl-D-aspartate (NMDA) and non-NMDA excitatory amino receptor antagonists that have led to a model of central sympathetic pathways that includes synaptic relays in the medullary lateral tegmental field (LTF) of the cat are summarized. Evidence is presented that (1) the LTF contains a population of tonically active sympathoexcitatory neurons that drive rostral ventrolateral medullary neurons, (2) blockade of non-NMDA receptors in the LTF significantly reduces basal levels of sympathetic nerve discharge (SND) and mean arterial pressure in baroreceptor-denervated cats, and (3) blockade of NMDA-mediated neurotransmission in the LTF prevents baroreceptor reflex control of SND. Thus, LTF neurons play an important role in the generation and baroreceptor reflex control of SND in the cat.
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Barman et al. (2001) reported a review. Central microinjections of NMDA and non-NMDA excitatory amino receptor antagonists was evaluated on Sympathetic nerve discharge (SND) and mean arterial pressure. Blockade of non-NMDA and NMDA receptors in the medullary lateral tegmental field reduces basal sympathetic nerve discharge and prevents baroreceptor reflex control in cats.
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